The Development of Endogenous CO and its Mechanism in Asthma
- VernacularTitle:内源性一氧化碳在哮喘中的变化与机制
- Author:
Hong WANG
;
Yan LONG
;
Jing WANG
;
Weili LUAN
- Publication Type:Journal Article
- From:
Chinese Pediatric Emergency Medicine
2001;8(1):20-21
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the development of endogenous CO and its mechanisms in asthma.Methods 50 guinea pigs were equally separated 5 groups.After the models of asthmatic guinea pigs were established in 4 groups,3 groups of them were treated with dexamethasone,the specific stimulator(hemin)and inhibitor(Sn-PP)of HO-1 respectively.The rest of groups were asthmatic one and normal control one(NCG).From all tested animals,the COHb in blood and lung HO-1 activity were examined,the lung tissues were pathologically observed and immunohistochemically stained.Results In asthmatic and hemin stimulated groups,the levels of COHb with enhanced expression of lung HO-1 and their activity were significantly increased compared with NCG(t=4.43～9.97,P＜0.01).For example,the lung HO-1 activities in asthmatic group were (881±361)pmol/(mg*pro*h),COHb (4.94±2.15)% respectively.In dexamethason prevented and Sn-PP inhibited groups,however,all determined levels were markedly reduced compared with asthmatic group(P＜0.01).Conclusion The increased HO-1 had resulted in the growth of endogenous CO in asthma.
