MHC Class II Positive Cells and Macrophages in the Iris of normal Lewis Rats.
- Author:
Young Bock HAN
1
Author Information
1. Department of Ophthalmology, College of Medicine Ewha Womans University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Immunohistochemistry;
MHC class II;
Dendritic cell;
Macrophages
- MeSH:
Animals;
Antibodies, Monoclonal;
Dendritic Cells;
Immunohistochemistry;
Iris*;
Macrophages*;
Rats*
- From:Journal of the Korean Ophthalmological Society
1998;39(10):2292-2297
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
To identify the MHC class II expressing cells and macrophages in the iris, immunohistochemistry was carried out using monoclonal antibodies specific to MHC class II antigens(OX6), resident tissue macrophages(ED2) and monocyte-macrophage lineage(ED1) on wholemounts of iris from normal Lewis rats. A number of OX6 positive cells are distributed evenly in the iris. Morphology of OX6 positive cells are dendritiform, round, or pleomorphic. OX6-positive and dendritiform cell are presumed to be dendritic cells. ED2 positive cells are more closely arranged than OX6 positive cells. Most of ED2 positive cells are dendritiform. Most of ED1 positive cells are round. These cells might have important roles in the process of immune mechanism to various antigens in the anterior segment of the eye.
