Interactions of the HSV-1 UL25 Capsid Protein with Cellular Microtubule-associated Protein
- Author:
Lei GUO
;
Ying ZHANG
;
Yanchun CHE
;
Wenjuan WU
;
Weizhong LI
;
Lichun WANG
;
Yun LIAO
;
Longding LIU
;
Qihan LI
- Publication Type:Journal Article
- Keywords:
HSV-1;
Capsid;
UL25;
Microtubule-associated protein
- From:
Virologica Sinica
2008;23(3):211-217
- CountryChina
- Language:Chinese
-
Abstract:
An interaction between the HSV-1 UL25 capsid protein and cellular microtubule-associated protein was found using a yeast two-hybrid screen and β-D-galactosidase activity assays. Immunofluorescence microscopy of the UL25 protein demonstrated its co-localization with cellular microtubule-associated protein in the plasma membrane. Further investigations with deletion mutants suggest that UL25 is likely to have a function in the nucleus.
