Intracellular Cytokine Detection in Peripheral Blood CD3＋ T Cells of Patients with Recurrent Genital Herpes
- VernacularTitle:复发性生殖器疱疹患者外周血 CD3＋ T细胞内细胞因子的检测
- Author:
Qifeng QIAN
;
Hongwei GUO
- Publication Type:Journal Article
- From:
Chinese Journal of Dermatology
2001;34(3):195-197
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the role of Th1/Th2 cytokine profile in the pathogenesis of recurrent genital herpes (RGH), and to find out the relationship between Th1/Th2 cytokines. Methods A two－ colour immunofluorescent staining of cell surface antigen and intracellular cytokines (IL－ 2、 IL－ 10、 IL－ 12、 IFN－ γ and TNF－ α ) in CD3＋ T－ lymphocytes of 20 patients with RGH with flow cytometric analysis were performed. Results Compared to controls, patients with RGH showed a decreased number of CD3＋ T cells（ P0.05） . Conclusions RGH patients seem to have a predominance of Th2 cytokine profile, which may play an important role in the pathogenesis of RGH.
