Current Status of Natural Products from Plants as Anti-herpes Simplex Virus 1 Agents
- Author:
Yangfei XIANG
;
Ying PEI
;
Yifei WANG
- Publication Type:Journal Article
- Keywords:
Herpes simplex virus 1 (HSV-I);
Antiviral;
Anti-HSV-1;
Natural product
- From:
Virologica Sinica
2008;23(5):305-314
- CountryChina
- Language:Chinese
-
Abstract:
Nucleoside analogues have been the mainstay of clinical treatment of herpes simplex virus 1 (HSV-1) infections since their development. However, the emergence of drug resistant strains has underlined the urgency of the discovery of novel anti-HSV-1 drugs. Natural products, which provided many novel drug leads, are known to be an important source of anti-HSV-1 agents. Herein, we present an overview of natural products with anti-HSV-1 activities isolated from a variety of plants reported in recent years. Several different compounds, mainly belonging to the three groups of polysaccharides, polyphenols and terpenes, showed antiviral effects against HSV-1, indicating their potential to be promising anti-HSV-1 agents.
