Improvement of a rat orthotopic left lung transplantation model
- VernacularTitle:大鼠左肺原位移植模型的改进
- Author:
Jing GE
;
Wei ZHAI
;
Jian TANG
;
Jianjun WANG
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2008;12(40):7995-7997
- CountryChina
- Language:Chinese
-
Abstract:
120 age- and body mass-matched Lewis rats underwent anastomosis of vessels and bronchus using cuff technique and 60 rats received orthotopic left lung transplantation. All procedures were done by one operator. The feasibility and reliability of this technique was determined by examining graft patency usng X-ray, gross and histological examinations. The successful rate of the surgery was 96.7%, mean warm ischemic time was (14.5±3.2)min. On gross examination, grafts were well perfused and ventilated.Recipients of 14d after transplantation showed excellent chest X-ray signs and perfect graft function. The animal model established in this study has been verified to be a safe, simple and reproducible model.
