The Herpes Simplex Virus Type 1 Multiple Function Protein ICP27
10.1007/s12250-008-2993-0
- Author:
Lei ZHAO
;
Wenbo ZHU
;
Qiong DING
;
Guiqiang PENG
;
Chunfu ZHENG
- Publication Type:Journal Article
- Keywords:
Herpes simplex virus type 1 (HSV-1);
Infected-cell protein 27 (ICP27);
Nuclear export;
Leptomycin B (LMB);
Interferon (IFN)
- From:
Virologica Sinica
2008;23(6):399-405
- CountryChina
- Language:Chinese
-
Abstract:
The herpes simplex virus type 1 (HSV-1) infected-cell protein 27 (ICP27) is an essential,highly conserved protein involved in various steps of HSV-1 gene regulation as well as in the shut-off of host gene expression during infection.It functions primarily at the post-transcriptional level in inhibiting precursor mRNA splicing and in promoting nuclear export of viral transcripts.Recently,many novel functions performed by the HSV-1 ICP27 protein were shown,including leptomycin B resistance,inhibition of the type I interferon signaling,regulation of the viral mRNA translation and determining the composition of HSV-1 virions.
