Angiogenesis,Kaposi's Sarcoma and Kaposi's Sarcomaassociated Herpesvirus
10.1007/s12250-008-2998-8
- Author:
Tao KANG
;
Fengchun YE
;
Shoujiang GAO
;
Linding WANG
- Publication Type:Journal Article
- Keywords:
Angiogenesis;
Kaposi's sarcoma (KS);
Kaposi's sarcoma-associated herpesvirus (KSHV)
- From:
Virologica Sinica
2008;23(6):449-458
- CountryChina
- Language:Chinese
-
Abstract:
Tumor angiogenesis is the uncontrolled growth of blood vessels in tumors,serving to supply nutrients and oxygen,and remove metabolic wastes.Kaposi's sarcoma (KS),a multifocal angioproliferative disorder characterized by spindle cell proliferation,neo-angiogenesis,inflammation,and edema,is associated with infection by Kaposi's sarcoma-associated herpesvirus (KSHV).Recent studies indicate that KSHV infection directly promotes angiogenesis and inflammation through an autocrine and paracrine mechanism by inducing pro-angiogenic and pro-inflammatory cytokines.Many of these cytokines are also expressed in KS lesions,implicating a direct role of KSI-IV in the pathogenesis of this malignancy.Several KSHV genes are involved in KSHV-induced angiogenesis.These studies have provided insights into the pathogenesis of KS,and identified potential therapeutic targets for this malignancy.
