An ER Locating Protein Named RCN2 Interacts With STIM1-Orai1 Complex
- VernacularTitle:内质网上的蛋白质RCN2与STIM1-Orai1复合体相互作用
- Author:
Yi ZHAN
;
Shangbang GAO
;
Peng XUE
;
Xiaofei YANG
;
Zhengzheng LI
;
Tao XU
- Publication Type:Journal Article
- Keywords:
RCN2;
STIM1;
Orai1;
TAP
- From:
Progress in Biochemistry and Biophysics
2008;35(11):1247-1253
- CountryChina
- Language:Chinese
-
Abstract:
STIM1 is recognized as an ER Ca2+ sensor of calcium release-activated calcium (CRAC) channel that is constructed by membrane protein Orai1, However, this regulatory system may also be regulated by other proteins. Reticulocalbin 2 (RCN2) was purified and identified from STIM1-Orai1 complex. Confocal microscopy revealed that RCN2 co-localized with STIM1 in ER before and after Ca2+ store depletion. Single cell [Ca2+]I measurements of RCN2 EF hands mutant showed slight influence on SOC electrophysiological characters. Furthermore, a novel collar form aggregation of RCN2 surrounding STIM1 clusters suggested that RCN2 potentially plays a role of structure maintenance in STIM1 clustering.
