Comparative analysis of immunological detection results in patients with POEMS syndrome
- VernacularTitle:POEMS综合征的免疫学检测结果分析
- Author:
Xihuan DONG
- Publication Type:Journal Article
- Keywords:
POEMS syndrome;
Immunoglobulins;
Electrophoresis
- From:
International Journal of Laboratory Medicine
2008;29(10):890-891
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the immunological feature, and to provide evidence for di-agnosis and treatment of POEMS syndrome. Methods The results detected with serum protein elec-trophoresis (SPE), immunofixation (IFE) and immunoglobulin quantitative assay were retrospectively compared and analyzed in 27 patients with POEMS syndrome. Results For 27 cases of POEMS syn-drome, the detection rate of M protein was significantly higher detected with IFE than that with SPE. Among M protein, IgA was much more frequent than IgG (16 cases vs 5 cases), and all were typeλ. Besides, there was statistical difference in SPE results between 16 cases of POEMS syndrome with M protein positive (detected with SPE) and healthy controls. Conclusion Negative M protein result can't exclude the diagnosis of POEMS syndrome. Further evidence should be searched for, and the clinical data should be emphasized
