Clinical significance of thyroid function indices and 99mTc thyroid uptake rote in the early hypothyroidism following 131I treatment of Graves' disease
- VernacularTitle:131I治疗Graves'病后早发甲低甲状腺功能指标及摄锝率测定的意义
- Author:
Li CHEN
- Publication Type:Journal Article
- Keywords:
Goiter diease;
Hypothyroidism;
Hyperthyroidism;
Complementary therapies
- From:
International Journal of Laboratory Medicine
2008;29(9):796-797
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical value of thyroid function indices and 99mTc thy-roid uptake rate in the early hypothyroidism following 131I treatment of Graves' disease. Methods 66 patients with early hypothyroidism following 131I treatment of Graves' disease,were enrolled in the in-vestigation. The thyroid funtion indices(FT3 ,FT4 and TSH) and 20 rain 99mTc throid uptake rate were determined before and after levothyroxine sodium replacement treatment. Results FT3 ,FT4 and 99mTc throid uptake rate in hypothyroidism group were significanthy lower than those in healthy control group,and TSH was significanthy higher (P<0.01). However, the differences of above parameters weren't statistically significant group between transient hypothyroidism and developing hypothyroidism group(P>0. 05). After replacement theraphy,the thyroid function and 99 mTc throid uptake rate recov-ered in transient hypothyroidism group. FT3,FT4 and 99mTc throid uptake rate in developing hypothy-roidism group were significanthy lower than those in healthy control group and transient hypothyroid-ism group,and TSH kept significanthy higher(P<0.01). Conclusion It isn't capable of differentia-ting transient and developing hypothyroidism with thyroid homone in dices and 99mTc thyroid uptake rate in the early phase. After a short time replacement therapy, the thyroid function and 99mTc throid uptake rate recover in transient hypothyroidism subjects,but don't recover in developing hypothyroid-ism subjects.
