Effect of strontium ranelate on bone resorption
- VernacularTitle:雷耐酸锶在骨吸收中的作用
- Author:
Yingming WAN
;
Jingyun WANG
;
Weimin WANG
;
Wan LI
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2008;12(50):9993-9996
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: Most of anti-osteoporosis drugs can only inhibit bone resorption, but can not improve the bone formation. So far, Strontium ranelate is the only anti-osteoporosis drug that has a dual effect on bone resorption and bone formation. Through the retrieval of related studies, the present review article evaluates the current understanding of strontium ranelate effects on bone resorption based on the pharmacologic experiments, clinical studies, action mechanisms. Recombinant human bone morphogenetic protein-2 (rhBMP-2) has been widely used on clinic; however, there are still few reports addressing rhBMP-2-induced osteogenesis in intervertebral disc.