Influence of indapamide on pharmacokinetics of telmisartan in male and female rats
10.3867/j.issn.1000-3002.2009.01.001
- VernacularTitle:吲达帕胺对大鼠替米沙坦药代动力学的影响及性别差异
- Author:
Mingxia WANG
;
Baoen SHAN
;
Weiwei LI
;
Min WANG
;
Xigai SU
- Publication Type:Journal Article
- Keywords:
telmisartan;
indapamide;
pharmacokinetics;
chromatography,high pressure liquid
- From:
Chinese Journal of Pharmacology and Toxicology
2009;23(1):1-5
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the influence of indapamide(Ind) on pharmacokinetics of telmisartan(Tel) and observe the difference between male and female rats. METHODS Wistar rats were divided into Tel and Tel+Ind groups, each group containing 8 female and 8 male rats, and were ig administered a single dose of either Tel 3.6 mg·kg-1 or Tel 3.6 mg·kg-1+Ind 0.135 mg·kg-1, respectively. Blood samples were collected at intervals over 96 h after administration. The Tel concentrations in plasma were determined by high performance liquid chromatography with fluorescence detector. The Tel concentration-time curves were simulated by 3p97 software and the pharmacokinetic parameters were calculated. RESULTS Whatever in female or male rats, there were no significant differences in the main pharmacokinetic parameters of Tel between Tel and Tel+Ind groups. However, females had higher values for area under the concentration-time curve and maximum plasma concentration than males, but lower values for total clearance in both Tel and Tel+Ind groups. CONCLUSION Ind has no significant influences on the pharmacokinetics of Tel. However, pharmacokinetics of Tel is significant different between male and female rats.
