Cell transplantation for child cerebral palsy
- VernacularTitle:细胞移植治疗小儿脑性瘫痪
- Author:
Bingqing ZHANG
;
Hongyun HUANE
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2008;12(53):10596-10600
- CountryChina
- Language:Chinese
-
Abstract:
Cerebral palsy, a non-progressive central dyskinesis caused by a variety of reasons. is one of the major diseases resulting in serious paralysis of children nervous system. At present there is no special treatment. and most are supporting and symptomatic treatments. In recent years, with development of recombinant DNA technology and cell biology. transgenic cell lines and cell line transplantation have become new focus of study in brain transplant. Currently the experimental studies on cell transplantation, especially stem cells. in the treatment of children cerebral palsy mainly refer to newborn animals with hypoxic-ischemic brain injury at acute phase. and have made some progresses. Studies have demonstrated that stem cells can survive longest for eight months after transplanted into the brain. and can migrate to the damage a/ca and differentiate into different phenotypes of nerve cells to improve partly neuroethology disorder. However. that transplanted stem cells differentiate into minimal target neurons may be ode of main reasons that cannot achieve ideal effects.
