Functional Analyses of Mammalian Reovirus Nonstructural Protein μNS
10.1007/s12250-009-3016-5
- Author:
Chao FAN
;
Qin FANG
- Publication Type:Journal Article
- Keywords:
dsRNA virus;
Mammalian orthoreoviruses;
Nonstructural protein μNS
- From:
Virologica Sinica
2009;24(1):1-8
- CountryChina
- Language:Chinese
-
Abstract:
Genome replication of reovirus occurs in cytoplasmic inclusion bodies called viral factories or viroplasms. The viral nonstructural protein μNS, encoded by genome segment M3, is not a component of mature virions, but is expressed to high levels in infected cells and is concentrated in the infected cell factory matrix. Recent studies have demonstrated that μNS plays a central role in forming the matrix of these structures, as well as in recruiting other components to them for putative roles in genome replication and particle assembly.
