Clinical value of determination of serum total bile acid in hepatic lesion in hemolytic disease of the newborn
10.3760/cma.j.issn.1673-4130.2009.01.010
- VernacularTitle:血清总胆汁酸在新生儿溶血患者肝损害中的临床观察
- Author:
Dehong FEI
;
Fengqiong HE
;
Yongqian YAN
- Publication Type:Journal Article
- Keywords:
Bile acids and salts;
Hemolysis;
Infant，newborn;
Liver function tests
- From:
International Journal of Laboratory Medicine
2009;30(1):26-27
- CountryChina
- Language:Chinese
-
Abstract:
Objective To further confirm the clinical value of serum total bile acid (TBA) in hepatic lesion in patients with hemolytic disease of the newborn.Methods Enzyme circulation assay was applied to measuring in 68 patients with hemolytic disease of the newborn. Total bilirubin (TBIL), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and γ-glutamyltransferase (GGT) were measured simultaneously.Results The serum level of TBA was (27.63±4.83) mmol/L in haemolysis group, significantly higher than that in control group (14.92±6.87) mmol/L (P<0.01). The positive rate accounted for 70.59% (48/68) in haemolysis group, and serum level of TBA was positively correlative with liver functional parameters (TBIL, ALT, GGT and ALP).Conclusion Serum TBA may be used as an indicator of therapeutic effect monitoring and prognosis evaluation of hepatic lesion in patients with hemolytic disease of the newborn.
