Study on the correlation between hs-CRP and coronary heart disease as well as acute myocardial infarction
10.3760/cma.j.issn.1673-4130.2009.01.014
- VernacularTitle:超敏C-反应蛋白与冠心病、心肌梗死的相关性探讨
- Author:
Ying WU
;
Chongji CHEN
- Publication Type:Journal Article
- Keywords:
Coronary disease;
Myocardial infarction;
C-reactive protein
- From:
International Journal of Laboratory Medicine
2009;30(1):36-38
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between high-sensitivity C-reactive protein (hs-CRP) and the occurrence of certain diseases such as coronary heart disease (CHD) and acute myocardial infarction (AMI).Methods Sixty-one CHD patients, 45 AMI patients (patients group, excluding high hs-CRP level diseases caused by other etiological factors) and 35 healthy controls (control group) were enrolled in the study. The serum level of hs-CRP and myocardial zymogram was measured in the Hitachi 7060 automatic analyzer by latex-enhance immunoturbidimetry for all subjects, and cTnI of AMI group was detected with immunofluorescence method at the same time. The difference of hs-CRP level was compared and analyzed between control group and patients group; control group before and after treatment. Moreover, the relationship between hs-CRP and myocardial zymogram as well as cTnI was analyzed.Results The level of hs-CRP was significantly higher in patients group than that in control group (P<0.01). There was statistical difference of hs-CRP level before and after treatment in control group (P<0.01). hs-CRP was positively correlative with myocardial zymogram and cTnI.Conclusion The serum level of hs-CRP is significantly elevated in CHD and AMI patients, indicating the measurement of hs-CRP contributes to auxiliary diagnosis, therapeutic effect observation, and prognosis evaluation.
