Expression of VEGF-C and VEGFR-3 in breast cancer tissue and its clinical significance
10.3760/cma.j.issn.1673-4130.2009.01.005
- VernacularTitle:VEGF-C和VEGFR-3在乳腺癌的表达及其意义
- Author:
Jinrui FU
;
Lina SUN
;
Zhenfen ZHANG
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Vascular endothelial growth factor C;
Vascular endothelial growth factor receptor-3
- From:
International Journal of Laboratory Medicine
2009;30(1):11-13
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of vascular endothelial cell growth factor-C (VEGF-C) and its receptor--vascular endothelial cell growth factor receptor-3 (VEGFR-3) in breast cancer tissue and its correlation with metastasis of lymphonodi axillares.Methods Fifty-eight cases of breast cancer samples and 10 cases of tumor adjacent non-carcinomatous tissue were measured by immunohistochemical staining for expression of VEGF-C and VEGFR-3. Their expression rates were compared between axillary lymph node metastasis and non-metastasis groups.Results The positive rates of VEGF-C and VEGFR-3 as well as the number of VEGFR-3 positive vessels were significantly higher than those in lymph node non-metastasis group (87.5% vs 55.9%; 83.3% vs 38.2%; 8.54±2.54 vs 4.73±2.46, respectively).Conclusion The high expression of VEGF-C and VEGFR-3 as well as the increase in the number of VEGFR-3 positive vessels are related to lymph node metastasis of human breast cancer. VEGF-C/VEGFR-3 system may be a new specific target which contributes to blockage of lymphatic metastasis in breast cancer.
