The clinical value of N-terminal pro-brain natriuretic peptide quantitative detection in diagnosis of heart failure
10.3760/cma.j.issn.1673-4130.2009.01.009
- VernacularTitle:定量检测N末端脑钠肽对心衰的诊断价值
- Author:
Longhai WANG
;
Ping ZHANG
;
Qisong CHEN
- Publication Type:Journal Article
- Keywords:
Natriuretic peptide，brain;
Heart failure，congestive;
Diagnosis
- From:
International Journal of Laboratory Medicine
2009;30(1):23-25
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the diagnostic value of N-terminal pro-brain natriuretic peptide (NT-proBNP) quantitative detection in patients with heart failure.Methods Quantitative enzyme-linked immunosorbent assay (ELISA) improvement method was applied to measuring serum level of NT-proBNP in patients with different degree of heart failure.Results The serum level of NT-proBNP was significantly elevated in patients with heart failure. With the increase of extent of heart failure, NT-proBNP increased in exponent. Receiver operator characteristic curve (ROC) showed that area under curve (AUC) was 0.898. The sensitivity and specificity were 91.9% and 92.3% respectively for diagnosis of heart failure.Conclusion Quantitative detection of NT-proBNP is at present the best laboratory test for evaluating heart function of patients with heart failure.
