Sec-10 Knockout Increases The Neuroactive-drug Responses Without Affecting Function of The Postsynaptic Ionotropic Receptors in Neuromuscular Junctions
10.3724/SP.J.1206.2009.00100
- VernacularTitle:Sec-10影响神经肌肉接头突触后敏感性的研究
- Author:
Lei ZHANG
;
Jiangli LI
;
Shangbang GAO
;
Zhengxing WU
;
Rongying ZHANG
;
Tao XU
- Publication Type:Journal Article
- Keywords:
exocyst complex;
sec-10;
NMJs;
ionotropic receptors
- From:
Progress in Biochemistry and Biophysics
2009;36(4):410-416
- CountryChina
- Language:Chinese
-
Abstract:
Exocyst complex is known to function in the exocytosis network, however, the molecular mechanism is unclear yet. Using UV/trimethylpsoralen mutagenesis, the sec-10 (one component of the exocyst complex) knockout mutant of C. elegans was obtained for the first time. The drug sensitive assays revealed clearly that the sec-10 gene affected the neural signal transmission, however, the electrophysiological assay showed the function of the ionotropic receptors in the neuromuscular junctions (NMJs) were unaltered compared with the wild type (WT). Thus it was assumed that the sec-10 gene might not influence the known ionotropic receptors in the NMJs, but some other pathways instead.
