Intralesional injection of two kinds of glucocorticosteroid for the treatment of active alopecia areata: a comparative study
10.3760/cma.j.issn.0412-4030.2011.04.021
- VernacularTitle:两种糖皮质激素注射液皮损内注射治疗活动期斑秃的临床疗效观察
- Author:
Jin YUAN
;
Wenyu WU
;
Mengmeng SONG
;
Wenwen FU
- Publication Type:Journal Article
- From:
Chinese Journal of Dermatology
2011;44(4):285-287
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the clinical efficacy of intralesional betamethasone versus triamcinolone acetonide acetate in the treatment of active alopecia areata. Methods A total of 160 patients with active alopecia areata were divided into two groups, test group (n = 100) treated with intralesional betamethasone, and control group (n = 60) treated with intralesional triamcinolone acetonide. Both injections were given once every 3 weeks for 12 consecutive weeks. Results After 12-week treatment, the cure rate, response rate, and total response rate were 60.0%, 32.0% and 92.0% in the test group, respectively, compared to 41.7%, 31.67% and 73.3% in the control group, respectively. A significant increase was observed in the cure rate and response rate in the test group compared with the control group (χ2 = 10.25, 5.06, P < 0.01 and 0.05). During the treatment course, 8 (8%) patients in the test group and 9 (15%) patients in the control group developed localized atrophy of the scalp; 8 (8%) patients in the test group and 3 (5%) patients in the control group developed localized folliculitis; no significant difference was observed between the two groups in the occurrence of adverse reactions (P> 0.05). Conclusion Intralesional use of compound betamethasone injection has a notable therapeutic effect on alopecia areata.
