Autologous bone marrow stem cell transplantation for treating myocardial infarction in 6 cases A 4 years follow-up
- VernacularTitle:自体骨髓干细胞移植治疗心肌梗死6例4年随访
- Author:
Shuixiang YANG
;
Jing XU
;
Guiyu XU
;
Haojie DAI
;
Jiahe TIAN
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2009;13(10):1969-1972
- CountryChina
- Language:Chinese
-
Abstract:
Six patients with ST segment elevated acute myocardial infarction (AMI), who were 52.5 years old in average, were enrolled and performed the treatment at Tongren Hospital from November 2003 to June 2004. Following percutanecus transluminal coronary angioplasty and stent revascularization, autologous bone marrow stem cell (BMSC) transplantation was performed after informed consent was obtained. Patients were subcutaneously injected with granulocyte colony-stimulating factor (G-CSF) at 1 week before transplantation. When CD34+ cells going up to 1%-3% in peripheral blood, mononuclear cells in peripheral blood were harvested,purified, and further infused into the infarcted related coronary artery with an over-the-wire balloon catheter. Following up was performed every half a year. Four years later, the infarcted area of these patients was further decreased by 8.03%, in the basic descent of 42.7% at 3 months averagely; total infracted area descent was 50.73%, but ejection fraction increased by 4.6% from 50.8%. There was no serious coronary artery restenosis and/or stenosis formation which need revascularization upon angiography.
