HCMV Infection Depress NGF Expression in Human Glioma Cells
10.1007/s12250-009-3018-3
- Author:
Haitao WANG
;
Bin WANG
;
Zhijun LIU
;
Zhiqiang BAI
;
Ling LI
;
Dongmeng QIAN
;
Zhiyong YAN
;
Xuxia SONG
- Publication Type:Journal Article
- Keywords:
Human cytomegalovirus (HCMV);
U251 cell;
Nerve growth factor (NGF)
- From:
Virologica Sinica
2009;24(3):209-214
- CountryChina
- Language:Chinese
-
Abstract:
Human cytomegalovirus (HCMV) is the most common cause of congenital infection, resulting in birth defects such as microcephaly. In this study, RT-PCR and Western Blotting were performed to quantify the regulation of endogenic nerve growth factor expression in neuroglia cells by HCMV infection. The results showed that basal, endogenous NGF expression in U251 was unchanged during early HCMV infection. NGF expression is strongly down-regulated during the latent phase of infection. These results suggest that HCMV can depress the NGF expression in U251 cells.
