Novel environmental response and heroin-dependent susceptibility in Sprague-Dawley rats
- VernacularTitle:SD大鼠新奇环境反应性与海洛因依赖易感性的关系
- Author:
Chuansheng WANG
;
Hongxian CHEN
;
Wei HAO
- Publication Type:Journal Article
- Keywords:
heroin dependence;
conditioned place preference;
susceptibility;
novel environmental response
- From:
Journal of Central South University(Medical Sciences)
2009;34(4):277-281
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish models of different susceptibility of heroin-induced conditioned place preference (CPP) in rats and investigate the relation between novel environmental response and heroin-dependent susceptibility. Methods After an open-field test, 70 male Sprague-Dawley rats were classified into 2 groups according to the numerical value of heroin-induced CPP, each accounting for 30%. The correlation between open-field test and CPP was analyzed. Results CPP value was much higher than pre-test scores in the rats after exposure to heroin (P<0.01). Compared with the low-CPP group, the high-CPP group had much higher scores in open-field test (P<0.01). The deviation of resident time at natural preference side tested and pre-tested had positive correlation with open-field test (P<0.05). Conclusion Heroin-induced CPP model of different susceptibilities could be successfully established by chronic heroin exposure. The novel environmental response is a reliable predictor for its vulnerability to develop heroin dependence.
