Surface modification of small-diameter vascular prosthesis
10.3969/j.issn.1673-8225.2009.16.045
- VernacularTitle:小口径人工血管表面的改性
- Author:
Chengyong XIA
;
Changjian LIU
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2009;13(16):3197-3200
- CountryChina
- Language:Chinese
-
Abstract:
Vascular prosthesis can absorb y-globulin or fibrinogen when they are transplanted in vivo, accordingly the cellular components in blood, such as platelet, are easy to attach on surface and become fiat shape to be activated, which then result in an inreversible aggregation and thrombus formation. During the process of transplanting vascular prosthesis at a diameter of more than 6 mm, a high vascular patency rate can be observed, while small-diameter (< 6 mm) vascular prosthesis transplantation is under low blood flow, therefore it produces the thrombosis. It is necessary to conduct surface modification of small-diameter vascular prosthesis and to enhance hemocompatibility. The main methods of modification include the alter of surface structure of vascular prosthesis, the augmentation of endothelial cells attachment on surface of vascular prosthesis, and grafting modification of vascular prosthesis surface.
