Preparation of intramyocardial bilayered porous biodegradable drug delivery stents
10.3969/j.issn.1673-8225.2009.22.039
- VernacularTitle:心肌内双层多孔生物可降解性药物缓释支架的制备
- Author:
Feng Lü
;
Tianjun LIU
;
Jian ZHAO
;
Xiaocheng LIU
;
Cunxian SONG
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2009;13(22):4374-4376
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare an intramyocardial bilayered porous biodegradable drug delivery stent and to evaluate its effects on myocardial channel after transmyocardial revascularization (TMR).METHODS:A biodegradable drug delivery stent was prepared by using poly (ε-caprolactone) (PCL),bovine serum albumin (BSA)and poly (D,L-lactide-co-glycolide) (PLGA).The levels of BSA in stent and released in vitro were determined by the Coomassie brilliant blue assay.The mechanical strength of stent was tested by universal material testing machines.Porcine models of chronic myocardial ischemia were created to evaluate the effects of this stent on myocardial channel after TMR,RESULTS:Each bilayered porous stent could carry 10 mg BSA and release about 80% of BSA after 30 days.The stent diminished 80% of initial scale under the stress of 1.2 MPa.It could keep myocardial channel patency after TMR.CONCLUSION:An intramyocardial bilayered porous biodegradable drug delivery stent was successfully prepared.It could sustain the pressure from the heart and maintain myocardial channel patency after TMR.
