The protective effect of low dose whole body γ-irradiation on dopaminergie neuron in C57 mice
10.3760/cma.j.issn.1673-4130.2009.05.010
- VernacularTitle:低剂量γ射线照射对小鼠多巴胺能神经元的保护作用
- Author:
Bing LIU
- Publication Type:Journal Article
- Keywords:
Parkinson disease;
Radiation,Ionizing;
Neurons
- From:
International Journal of Laboratory Medicine
2009;30(5):446-448
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the possible protective effect of low dose whole body γ-irradia-tion on dopaminergic neuron. Methods In 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-in-duced injury mice model,the levels of dopamine (DA) and its metabolites in striata of mice were detec-ted by igh performance liquid chromatogram (HPLC), and neurons (dopaminergic neuron, activated gitter cell and horizontal cell) were counted by immunohistochemical staining after low dose whole body irradiation. Results 3.5 Gy irradiation significantly restored the levels of DA and its metabolites decreased by MPTP. Conclnsion Low dose whole-body γ-irradiation does offer neuroproteetion againstMPTP- mediated damage of striatal dopaminergic nerve fibers.
