The examination and the expression of urotensin Ⅱ and their relationship with pre-eclampsia
10.3760/cma.j.issn.1673-4130.2009.05.015
- VernacularTitle:尿紧张素Ⅱ检测及表达与子痫前期孕妇的关系研究
- Author:
Shunfeng ZHAO
- Publication Type:Journal Article
- Keywords:
Urotensins;
Pre-eclampsia;
Serum;
placenta
- From:
International Journal of Laboratory Medicine
2009;30(5):459-460
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of urotensin Ⅱ (U Ⅱ) in occurrence and development of pre-eclampsia through the examination of U Ⅱ in pre-eclampsia pregnant woman and newborn cord blood and the expression of U Ⅱ mRNA in placenta. Methods 1) The serum U Ⅱ of peripheral blood and newborn cord blood was determined in 40 pre-eclampsia patients and 20 normal pregnant women (control group) by using ELISA method. 2) The U Ⅱ mRNA expression level in placenta tissue was simultaneously examined with RT-PCR method. Results The concentration o{ serum U Ⅱ in pre-eclampia patients was obviously higher than that in control group (P<0.05).2) The U Ⅱ mRNA ex-pression level in placenta tissue in pre-eclampsia patients was obviously higher than that in control group (P<0.05). Conclusion U Ⅱ plays an important role in development of ischemia, anoxemia and atherosclerosis of placenta tissue.
