Pharmacodynamics of rocuronium in infants with obstructive jaundice
- VernacularTitle:罗库溴铵用于梗阻性肝胆疾病小婴儿的肌松效应
- Author:
Zhijian ZHOU
;
Xuan WANG
;
Xuefeng ZHANG
- Publication Type:Journal Article
- Keywords:
Rocuronium;
Neuromuscular block;
Bitiary atresia
- From:
The Journal of Clinical Anesthesiology
2009;25(5):401-402
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the pharmacodynamics of rocuronium in infants with obstructive jaundice. Methods Thirty infants aged 1 to 4 months without neuromuscular diseases or renal dysfunction were divided into two groups with 15 cases each. The patients in group A were diagnosed with biliary atresia and scheduled for the kasai operation, and those in group B were with normal liver function and scheduled for abdominal surgery as the controls. Anestheisa was induced with propofol 2 mg/kg and fentanyl 3 g/kg. Rocuronium 0. 6 mg/kg was given and neuromuscular block was recorded with acceleromyography. Results Comparing with group B, The onset time of rocuronium was significantly longer in group A than that in group B[(81±35) s vs (51±28)s](P< 0. 05). There were no significant differences between the two groups in the maximum depression time [(49±15) min vs. (48±12) min]or the clinical duration of action[(76±20) min vs. (71±14) min]. Conclusion The onset time of rocuronium is prolonged in infants with obstructive jaundice.
