The Study on the Mechanisms of Early sensorineural Hearing Loss in Diabetic Rats

VernacularTitle:糖尿病早期内耳损伤听力学改变的实验研究
Author: Fuji LUO ; Xiaowan OHEN ; Weiming LUO
Publication Type:Journal Article
Keywords: Diabetes; Sensorineural hearing loss; DPOAE; Oxygen free radical
From: Journal of Audiology and Speech Pathology 2009;17(3):265-267
CountryChina
Language:Chinese
Abstract: Objective To investigate the mechanisms of early sensorineural hearing loss of diabetic rats. Methods The diabetic model for rats was established. Every rat was checked with ABR and DPOAE before and af-ter treatment . After 14 days , the blood glucose, blood fat, SOD, GSH-Px and MDA were measured. Results For the model group, the rats" blood glucose and fat increased while the GSH-Px was reduced more than the con-trol group. The response amplitudes of DPOAE decreased at 4 000 Hz and 8 000 Hz(P<0. 05). Conclusion The damage to the hair cells caused by the affected metabolism is considered as the culprit of the sensorineural hearing loss and the changes of DPOAE took place earlier than that of ABR, thus becoming useful in detecting early hearing loss of the diabetic patients.