Expressions of HER-2,p53,Estrogen Receptor,and Progesterone Receptor in Tissues of Invasive Ductal Breast Carcinoma with Different Clinical Stages
- VernacularTitle:人类表皮生长因子、p53、雌激素受体及孕激素受体在不同临床期别乳腺浸润性导管癌组织中的表达
- Author:
Luying TANG
;
Yi JIN
;
Yong LIU
;
Zhiying FENG
;
Chunkui SHAO
;
Zefang REN
- Publication Type:Journal Article
- Keywords:
immunohistochemistry;
HER-2;
p53;
ER;
PR;
rank test
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2009;30(4):454-457
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] Expressions of human epidermal growth factor receptor 2(HER-2),p53,estrogen receptor (ER),and progesterone receptor (PR) in tissues of breast invasive ductal carcinoma are not only applied to determine the therapeutic regimen,but they may also be related to the prognosis.We investigated the levels of these proteins among different clinical stages and the correlations.[Method] One hundred and thirty-eight tissues from cases with breast invasive ductal carcinoma were tested with immunohistochemistry.New scoring standards and rank test were applied.The indices were digitalized and semi-quantified.[Results] In the tissues from high clinical stage,the expression of HER2 was significantly increased,while expression of PR was markedly decreased.[Conclusion] Expression of HER2 and PR might be better markers for predicting clinical stages and prognosis.
