Determination of Methanol in Huoxiang Zhengqi Tincture by Headspace-Gas Chromatography
- VernacularTitle:顶空气相色谱法测定藿香正气水中的甲醇量
- Author:
Fang FANG
;
Naiying WU
;
Xiang LI
;
Fei XU
- Publication Type:Journal Article
- Keywords:
Headspace-gas chromatography;
Huoxiang zhengqi tincture;
Capillary column;
Content of methanol
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
2009;20(4):351-353
- CountryChina
- Language:Chinese
-
Abstract:
Objective A headspace-gas chromatography method was established for determination of methanol in Huox-iang Zhengqi Tincture. Methods Headspace-gas chromatography was performed on a HP-INNOWAX capillary col-umn, with nitrogen as carrier gas and FID as detector. The injector temperature was at 150℃ and the detector tempera-ture was at 200℃ , and temperature programming and split stream sampling were used. Results A good linearity was obtained within the designed range, the average recovery was 98.89 % with the RSD of 1.36 %, which met the correla-tive criterion of China Pharmacopoeia. Conclusion This method is proved to be accurate, and it has a good reproducibil-ity and can be used to determinate the residual methanol in Huoxiang Zhengqi Tincture.
