Determination of Menthol in Chuanbei Pipa Syrup by GC
- VernacularTitle:GC法测定市售川贝枇杷糖浆中薄荷脑含量
- Author:
Yongmei HUANG
;
Hong LI
;
Yuzhi SU
- Publication Type:Journal Article
- Keywords:
Chuanbei Pipa syrup;
Menthol;
Determination;
GC
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
2009;20(4):361-363
- CountryChina
- Language:Chinese
-
Abstract:
Objective To test the content of menthol in Chuanbei Pipa Syrup(CPS)by GC, and to evaluate its quality. Meth-ods The content of menthol in CPS was determined by capillary gas chromatography. DB-WAX capillary column (30 m ×0. 319 mm × 0. 50μm) was used with nitrogen as carrier gas. The precolumn pressure was 500 kPa and the column temperature was at 110 ℃ with split ratio of 25 : 1. The temperature was set at 250℃ for sample injection and for the detector. Results The content of menthol in CPS produced by Henan Pharmaceutical Co. , Ltd. , Zhengzhou Pharmaceutical Co. , Ltd. and Yunan Pharmaceutical Co. , Ltd. was 0. 154 mg/mL, 0. 203 mg/mL and 0. 109 mg/mL, respectively. Of them, the men-thol content in CPS produced by Zhengzhou Pharmaceutical Co. , Ltd. met the requirements of Pharmacopoeia(2005 edition), and that of the other two species was slightly lower. Conclusion The methods are convenient, reliable and accurate for the de-termination of menthol content in Chuanbei Pipa Syrup.
