The abnormal expressions of immunoglobulin light chains Kappa and Lambda in malignant tumors
10.3760/cma.j.issn.1673-4130.2009.06.014
- VernacularTitle:恶性肿瘤患者血清Kappa与Lambda轻链检测及临床意义
- Author:
Hong YAO
;
Yongai LIN
;
Zhongying ZHANG
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Immunoglobulin light chains;
Nephelometry and turbidimetry
- From:
International Journal of Laboratory Medicine
2009;30(6):562-563
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the abnormal expressions of immunoglobulin light chains kappa(Igκ)and Lambda(Igλ)in malignant tumors.Methods The concentrations of the Igκ and Igλ in serum were measured by rat nephelometry in 60 cases of malignant tumors and 15 cases of healthy people.Results The liver tumor patients had a higher concentration of Igκ and Igλ in serum than normal people(P＜0.01).There wre not significant differences between the levels of Igκ,Igλ and κ/λ ratio in the stomach tumor,lung tumor,proctologic/colonic tumor,mammary tumor,oesophagus tumor and normal peoples(P＞0.05).Conclusion The measurment of Igκ,Igλ and κ/λ ratio in serum would be helpful for the diagnosis of the liver tumor.By continous observation with Igκ,Igλ and κ/λratio in serum could predict the development of disease.
