Effect of neoadjuvant chemotherapy and radiotherapy in advanced local cervical cancer

VernacularTitle:新辅助化疗联合放疗在局部晚期宫颈癌治疗中的作用
Author: Xueqing HUO ; Jianhong XING ; Lingping ZHANG ; Hongjing ZHAN
Publication Type:Journal Article
Keywords: Uterine cervical neoplasms; Antineoplastic combined chemotherapy protocols; Radiotherapy,computer-assisted
From: Chinese Journal of Primary Medicine and Pharmacy 2011;18(3):343-345
CountryChina
Language:Chinese
Abstract: Objective To investigate the clinical effect of Paclitaxel and Cisplatin(TP) combined with radiotherapy and clinical security in advanced local cervical cancer. Methods After informed consent,80 patients with cervical canco were studied prospectively,and divided into TP combined with radiotherapy group(40 cases,observation group) ,and surgery group(40 cases,control group). The clinical effect and adverse reactions were analyzed. Results Total effective rate in study group was 80. 0% ,50. 0% in control group,the difference showed statistical significance(x2 =3.47,P ＜0.05).The transfer rate of pelvis lymph node was 5. 0% in observation group,22. 5% in control group, the difference showed statistical significance( x2 = 4. 78 ,P ＜ 0. 05). The difference of adverse reactions between two groups showed no statistical significance( P ＞ 0. 05). Conclusion Clinical effect of Paclitaxel and Cisplatin combined with radiotherapy was obvious in advanced local cervical cancer patients,with little side effect,and could be applied to clinical practice.