Effects of Berberine Combined with Magnolol and Honokiol on the Formation of THP-1 Macrophage-derived Foam Cells
- VernacularTitle:小檗碱联合厚朴酚及和厚朴酚对THP-1巨噬细胞源性泡沫细胞形成的影响
- Author:
Shuling WANG
;
Lian ZHOU
;
Qing WANG
;
Peixun WANG
- Publication Type:Journal Article
- Keywords:
Berberine;
Magnolol;
Bonokiol;
Tumor necrosis factor-α;
CD36
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
2009;20(4):297-300
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects and mechanism of berberine in combination with magnolol and honokiol on the formation of THP-1 macrophage-derived foam cells. Methods THP-1 macrophages were induced into foam cells by ox-LDL, and intracellular cholesterol in foam cells was determined by HPLC-MS; the concentration of tumor necrosis factor-α in the supernate of THP-1 macrophages was tested by ELISA and cell-surface CD36 level was assessed byflow cytometry. Results Combined treatment of berberine, magnolol and honokiol significantly reduced cholesterol con-tent in foam cells, also inhibited expression of tumor necrosis factor-α and CD36 in THP-1 macrophage. Conclusion Co-administration of berberine, magnolol and honokiol can inhibit the formation of foam cells probably through, down-regulating the level of tumor necrosis factor-α and CD36.
