The Investigation of Solubility of Asarone and Inclusion of Hydroxypropyl Cyclodextrin
- VernacularTitle:细辛脑溶解度及羟丙基环糊精包合作用的考察
- Author:
Guangming WANG
;
Yan TAO
;
Qiuling KONG
;
Jun TIAN
- Publication Type:Journal Article
- Keywords:
Asarone;
Solubility;
Hydroxypropyl cyclodextrin
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
2009;20(4):371-372
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate effects of different solvent, different temperature and different concentration of hydroxypropyl cyclodextrin on solubility of asarone. Method Determination of asarone solubility in different solvent, at different temperature and different concentration of cyclodextrin were carried out by HPLC-UV method. Results The solubility of asarone in water, tea oil, ethanol, and methanol were 0. 1 mg·mL-1 13.44 mg·mL-1, 1.87 mg·mL-1 and 1.76 mg·mL-1, respectively. The concentration and temperature of cyclodextrin showed a positive correlation with solubility of asarone. At normal temperature, the solubility of asarone in water increased 10 times by 45 % hydroxypropyl cyclodextrin. Conclusion Asarone has poor solubility in water and it can be improved by high concentration of hydroxypropyl cyelodetrin.
