Compound Betameth Pharmacokinetics in Plasma of Guinea Pig after Postaurieal Injection
- VernacularTitle:耳后注射复方倍他米松豚鼠血浆中药代动力学特征
- Author:
Yuanyuan JING
;
Lisheng YU
;
Xingqi LI
- Publication Type:Journal Article
- Keywords:
Compound betameth;
Administration route;
Pharmacokinetics
- From:
Journal of Audiology and Speech Pathology
2009;17(4):354-357
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate plasma pharmacokinetics profiles of compound betameth in guinea pig after postaurieal and systemic administrations,and to explore the possible pathway for postaurical injection. Methods 1 ml compound-betameth was injected postaurieally and intramuscularly into the guinea pig. Blood were samples obtained 0. 5,1,1.5,2,3,5,7 h and 1,2,4 w after the administration of contralateral sigmoid sinus blood and circulatory blood respectively. High performance liquid chromatography was used to dectet compound betameth in the samlowing postaurieal administration. The Cmax(peak concentration) in sigmoid sinus of postaurieal group was 2.56 and 3.03 higher than those in the contralateral and the systemic group. The AUC((area under the ct curve) was 2.41 postaurieal administration. The Cmax and AUC in postaurieal group were 0. 13 and 0. 32 higher than systemic group. Conclusion The postaurieal injection reached a higher concentration of drugs in the sigmoid sinus blood, and remained a lower concentration in circulatory blood.
