Levamisole-Induced Reversible Agranulocytosis in Children with Steroid Dependent Nephrotic Syndrome.
- Author:
Su Jin LEE
1
;
Su Ja HWANG
;
Eun Seon YOO
;
Seung Joo LEE
Author Information
1. Department of Pediatrics, College of Medicine, Ewha Womans University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Levamisole;
Agranulocytosis;
Steroid dependent nephrotic syndrome
- MeSH:
Adolescent;
Agranulocytosis*;
Autoimmune Diseases;
Child*;
Female;
Humans;
Levamisole;
Nephrotic Syndrome*
- From:Journal of the Korean Pediatric Society
1999;42(4):576-579
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Levamisole has been used for nephrotic syndrome due to its immunostimulating, immunomodulating, and steroid-sparing effects. Agranulocytosis, a serious side effect of levamisole, was rare and mostly associated with autoimmune disease, neoplastic disease and HLA B27 except one case in a nephrotic syndrome who was treated with high-dose(5mg/kg QOD) levamisole. This 15 year-old girl with steroid dependent nephrotic syndrome, who was negative for HLA B27, was treated with the usual recommended dose of levamisole(2.5mg/kg QOD). She developed agranulocytosis after 5 weeks of therapy and completely recovered in 11 days after discontinuation of levamisole.
