Cytotoxicity of zearalenone for thymic epithelial cells in mice
- VernacularTitle:玉米赤霉烯酮对小鼠胸腺上皮细胞的毒性作用
- Author:
Zisen LIANG
;
Lina XU
;
Yongjiang MA
;
Xianbo DENG
;
Ying LI
;
Xiaolong FAN
;
Yugu LI
;
Zhangyong NING
- Publication Type:Journal Article
- Keywords:
zearaleone;
cell proliferation;
cell cycle;
thymic epithelial cells;
mouse
- From:
Chinese Journal of Veterinary Science
2009;29(7):894-897
- CountryChina
- Language:Chinese
-
Abstract:
To elucidate the effects of Zearalenone(ZEA) on proliferation and cell cycle of cultured thymic epithelial cells in mice,trypan blue staining and flow cytometric analysis were performed.At the concentrations from 1 to 25 mg/L,ZEA displayed a significant inhibitory action to proliferation of thymic epithelial cells in its dose-and timedependent manner.Higher doses(10-25 rag/L)ZEA could induce a profound increase in G2/M phase with arrest of thymic epithelial cells in the G2/M phase in a dose-dependent manner.In conclusion,ZEA could be assumed that there were toxic effects on the thymie epithelial cells of mice in vitro.
