Toxic effect of oral ricin on the mouse intestinal tract and immune organs
- VernacularTitle:口服蓖麻毒素对小鼠肠道及免疫器官的毒性作用
- Author:
Linna LIU
;
Hongwei GAO
;
Ying DONG
;
Zhiping XIA
;
Xiaohuan ZOU
;
Jiping LI
;
Wensen LIU
;
Jiayu WAN
- Publication Type:Journal Article
- Keywords:
ricin;
intestinal tract damage;
immune organs damage
- From:
Chinese Journal of Veterinary Science
2009;29(7):898-900
- CountryChina
- Language:Chinese
-
Abstract:
The experiment aimed to study the toxic effect of oral ricin on gastrointestinal tract and immune organs of mice with the dose of 1/5 LD50.In early days of intoxication,there was an obviously decrease in daffy weight and relative weight of thymus and spleen,fllowing the excretion of toxin,they had a trend of recovering to the normal state.Also,results of pathological section,scanning electron microscope and transmission electron microscope showed that ricin would induce a series of pathological reaction in intestines,meanwhile,the splenocytes displayed significant symptom of apoptosis and necrosis.
