Factors that affect therapeutic effects of stem cell transplantation on myocardial infarction
10.3969/j.issn.1673-8225.2009.27.029
- VernacularTitle:影响干细胞移植治疗心肌梗死效果的因素分析
- Author:
Xinhua ZHAO
;
Delu YIN
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2009;13(27):5341-5344
- CountryChina
- Language:Chinese
-
Abstract:
After acute myocardial infarction, how realizes revasculadzation of the infarct area as well as prolongs the postponement left ventricle reconstruction and restores heart normal contraction function has been the hot spot. The research demonstrated that the transplanted stem cells may be in field planting of the heart infarct region, simultaneously through nutrition effects of secreting vascular endothelial cells and differentiation into myocardial cells, vascular endothelial calls, and can improve ventricle reconstitution and recovery cardiac function. However, stem call effects on myocardial infarction have close correlation to stem call tissue source. Various preconditioning also can affect repair of stem cells. Meanwhile, choice of suitable stem cell donors and recipients, correction of transplanted window and pathway are key factors for obtaining good clinical curative effects.
