Adipose derived mesenchymal stem cell transplantation for Alzheimer's disease
10.3969/j.issn.1673-8225.2009.27.040
- VernacularTitle:脂肪间充质干细胞移植治疗阿尔茨海默病
- Author:
Ying NIU
;
Kai GONG
;
Qiang AO
;
Nanming ZHAO
;
Xiufang ZHANG
;
Yandao GONG
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2009;13(27):5389-5392
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer's disease is an irreversible neurodegenerative disease characterized by progressive neuronal loss. To date, there has been no effective medicine or therapy for neurodegenerative disease. With development of stem cell technique and theory, neural stem cell transplantation has been found to be prospective in Alzheimer's disease treatment. However, it was challenged by the deficiency of autologous neural stem cell, which can bypass immunological barrier. Compared with neural stem cells, mesenchymal stem cells exhibit extensive resources, such as liver, bone marrow and adipose, and multiple differentiations into bone, muscle or adipose. Considering the easy access, the minor trauma to the patients, and the neuron differentiation potential of adipose derived mesenchymal stem cells (A-MSC), we hypothesize that A-MSC graft is a potential and innovative strategy for the treatment of Alzheimer's disease.
