Human adipose tissue-derived mesenchymal stem cells for treatment of refractory pure red cell aplasia after major ABO-incompatible hematopoietic stem cell transplantation
10.3969/j.issn.1673-8225.2009.27.042
- VernacularTitle:人脂肪源间充质干细胞治疗ABO血型不合造血干细胞移植后的顽固性单纯红细胞再生障碍性贫血2例
- Author:
Yufu LI
;
Ning LI
;
Yongping SONG
;
Gongli ZHANG
;
Quande LIN
;
Xudong WEI
;
Baijun FANG
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2009;13(27):5397-5400
- CountryChina
- Language:Chinese
-
Abstract:
The present study retrospectively analyzed 2 patients suffering from refractory pure red cell aplasia after major ABO-incompatible hematopoietic stem cell transplantation who received treatment in the Henan Institute of Haematology between April 2004 and February 2006. Patient 1 was a 25-year-old female with acute lymphocytic leukemia in second remission, and patient 2 was a 16-year-old gid with acute myeloid leukaemia in second remission. The two patients received a transplant of human adipose tissue-dedved mesenchymal stem cells (1.0×106/kg). Both of them acquired rapid recovery from pure red cell aplasia without any side effects. These findings suggest that adipose tissue-dedved mesenchymal stem cells seem to be a promising therapeutic option in patients with refractory pure red cell aplasia after ABO-incompatible hematopoietic stem cell transplantation, in whom conventional treatment fails.
