The expression and correlation between VEGF and TSP in oral submucous fibrosis

VernacularTitle:口腔黏膜下纤维化中VEGF和TSP表达及相关性的研究
Author: Jing WANG ; Juanfang ZHU ; Jieying PENG ; Quan XING ; Qin CAO
Publication Type:Journal Article
Keywords: Oral submucous fibrosis; Vascular endothelial growth factor; Thrombospondin
From: Journal of Practical Stomatology 2009;25(4):513-516
CountryChina
Language:Chinese
Abstract: Objective:To study the expressions of vascular endothelial growth factor(VEGF), and thrombospondin (TSP) in oral submucous fibrosis(OSF), and to determine the relationship between VEGF and TSP, so as to investigate their roles in the pathogenesis of OSF. Methods:30 patients with OSF, including early (10 cases), middle (10 cases), late stage (10 cases) were studied. 5 healthy volunteers were chosen as control group. Buccal mucosa biopsies were taken in all samples. Expressions of VEGF and TSP were detected by immunohistochemistry. Results:The expression of VEGF increased in early stage compared with normal oral mucous, and decreased in middle and late stage. The expression of VEGF in early stage had statistical difference compared with control group, middle stage and late stage respectively(P<0.05).The expression of TSP upregulated in early and middle, and downregulated in late stage. There were no statistical significant differences among groups(P>0.05). The expressions of VEGF and TSP had negative correlation(r=-0.620,P<0.05). Conclusions: The abnormal expressions of VEGF and TSP may be a pathogenesis factor of OSF.