Evaluation of the cytotoxicity of sodium hypochlorite and chloramine-T irrigants

VernacularTitle:根管冲洗剂次氯酸钠和氯亚明的细胞毒性
Author: Xiaoying ZOU ; Lin YUE
Publication Type:Journal Article
Keywords: Root canal irrigants; Sodium hypochlorite; Cytotoxicity
From: Journal of Practical Stomatology 2009;25(4):572-575
CountryChina
Language:Chinese
Abstract: Objective:To evaluate the cytotoxicity of sodium hypochlorite(NaOCl) and chloramine-T at a same available chlorine concentration. Methods: L929 fibroblasts were used to test the cytotoxicity of NaOCl and chloramine-T at a same available chlorine concentration (0.500 0%, 0.250 0%,0.200 0%, 0.150 0%, 0.125 0%, 0.062 5%). Cell viability after 2 h, 30 min or 10 min exposure were measured by MTT assay. Results: Except the 0.500 0%-2 h group and 0.062 5%-30 min group, cell viability of NaOCl groups were higher than chloramine-T group(P<0.05). Conclusion: NaOCl solution has less cytotoxicity than chloramine-T at a same available chlorine concentration lower than 0.250 0%.