Correlation study of tissue inhibitor of matrix metalloproteinase-1 gene polymorphisms and chronic periodontitis
10.3969/j.issn.1001-3733.2009.04.018
- VernacularTitle:基质金属蛋白酶组织抑制因子-1基因多态性与慢性牙周炎相关性研究
- Author:
Wenjun PENG
;
Dongying XUAN
;
Hongyu ZHAO
;
Xueyang ZHANG
;
Chunxian WANG
;
Hua ZHAO
;
Jincai ZHANG
- Publication Type:Journal Article
- Keywords:
Tissue inhibitor of matrix metalloproteinase;
Chronic periodontitis;
Single nucleotide polymorphism;
Allele
- From:
Journal of Practical Stomatology
2009;25(4):531-535
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the relationship between TIMP-1 gene polymorphisms and susceptibility of chronic periodontitis(CP) in Han Cantonese. Methods: Buccal swabs from 70 CP patients and 74 periodontal healthy controls were collected. DNA was extracted from these buccal swabs by using Chelex-100. TIMP-1 +372T/C (rs4898)、TIMP-1+533C/T (rs1062849) polymorphisms were tested by polymerase chain reaction - restriction fragment length polymorphism (PCR-RFLP). Allele distribution and genotypes frequencies in the patients and controls were analyzed. Results: Frequency variance of allele T and C at site of TIMP-1 +372 in patients and controls showed no statistical difference. TIMP-1+533C/T polymorphism of TIMP-1 hadn't been found in the present study. Conclusion: There is no relationship between TIMP-1 +372T/C polymorphism and susceptibility of chronic periodontitis, and TIMP-1 +533C/T polymorphism doesn' t exist among Han Cantonese.
