A clinical study on the relationship between neuropeptide substance P in gingival crevicular fluid and chronic periodontitis
10.3969/j.issn.1001-3733.2009.04.019
- VernacularTitle:龈沟液中神经肽P物质与慢性牙周炎关系临床研究
- Author:
Junping XIONG
;
Yage KONG
;
Pingsheng MA
;
Xu YANG
- Publication Type:Journal Article
- Keywords:
Gingival crevicular fluid;
Neuropeptide substance P;
Chronic periodontitis;
Correlation
- From:
Journal of Practical Stomatology
2009;25(4):536-539
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the relationship between occurrence and development of chronic periodontitis and neuropeptide substance P (SP) in gingival crevicular fluid. Methods: There were 48 patients in experimental group and 42 patients in the control group. Gingival crevicular fluid samples were collected from the patients′ intraoral chronic periodontitis inflammatory positive sites and healthy sites. Neuropeptide substance P levels in gingival crevicular fluid from two groups were measured by radioimmunoassay. Gingival index, pocket depth, attachment loss, alveolar bone resorption were recorded and their correlations with SP were analyzed. Results: SP levels of the experimental group were significantly higher than those of the control group(P<0.01). There were significant differences(P<0.01)between SP level and periodontal clinical index in slight periodontitis and the control group. There were significant correlations(P<0.05)between GCF SP content and all PD, AL, ABL but GI in slight periodontitis, and there were significant correlations in between GCF SP content and GI for both moderate periodontitis and severe periodontitis. There were significant correlations(P<0.01) between GCF SP content and PD,AL,ABL for both moderate periodontitis and severe periodontitis. Conclusion:GCF SP level is closely related to occurrence and development of chronic periodontitis.GCF SP level can reflect the degree of the damage of periodontium.Determination of patients′ GCF SP level has important significance for the patients′ condition judgement and treatment guidance.
