Role of activating transcription factor 2 in the growth of mandible condyle chondrocytes
10.3969/j.issn.1001-3733.2009.04.01
- VernacularTitle:活化转录调控因子2(ATF-2)在下颌骨髁突软骨细胞中调控bcl-2机制的研究
- Author:
Qin MA
;
Hong SONG
;
Xiaobing CHENG
;
Junrui ZHANG
;
Fulin CHEN
;
Wei WU
;
Tianqiu MAO
- Publication Type:Journal Article
- Keywords:
ATF-2;
Bcl-2;
Mandible Condyle;
Chondrocytes
- From:
Journal of Practical Stomatology
2009;25(4):459-462
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the role of activating transcription factor 2 (ATF-2) in the growth of mandibular condyle cartilage. Methods: Primary chondrocytes of condyle were cultured. Expression plasmid of ATF-2 and plasmid bcl-2 promoter were transfected into chondrocytes. Luciferase assay and Western blot were used. Results: The absence of ATF-2 in mandibular condyle chondrocytes resulted in a decline in bcl-2 promoter activity, reduction in bcl-2 protein level. Conclusion: The results strongly imply that ATF-2 is required for adequate bcl-2 expression, and play a significant role in controlling growth plate chondrocyte progression.
