Polymorphism of HLA-A and HLA-B in pre-eclampsia
10.3969/j.issn.1671-167X.2009.04.010
- VernacularTitle:HLA-A和HLA-B的多态性与先兆子痫
- Author:
Zhan ZHANG
;
Liting JIA
;
Linlin ZHANG
- Publication Type:Journal Article
- Keywords:
HLA A antigens;
HLA B antigens;
Pre-eclampsia;
Polymorphism,genetic;
Allele
- From:
Journal of Peking University(Health Sciences)
2009;41(4):418-425
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the association between the polymorphism of HLA-A, HLA-B genes and pre-eclampsia. Methods: HLA-A, HLA-B genotyping was performed by polymerase chain reaction sequence-specific primer (PCR-SSP) in 119 preeclampsia patients, 117 normal pregnant women and their neonates. Results: The study showed that 16 HLA-A and 39 HLA-B alleles were obtained in pre-eclamptic patients and normal pregnant women. 15 HLA-A and 37 HLA-B alleles were obtained in their neonates. No significant difference was found in maternal or neonatal HLA-A, HLA-B alleles be-tween pre-eclampsia group and control group (Pc>0. 05). The frequencies of HLA-A11, HLA-A24,HLA-B13, HLA-B14, HLA-B15, HLA-B52 maternal/fetus genetic assoications were significantly different between pre-eclampsia group and control group (P<0. 05). Conclusion: Some HLA-A, HLA-B maternal/fetus special bindings may be associated with the susceptibility or protective of pre-eclampsia.
